Introduction to microdosing psilocybin – Alchimia weblog


After our introductory article on psilocybin and its results, we wish to current you with a quick however full information on the right way to microdose your favorite magic mushrooms. On this event, we have now contacted Ana, a scientific psychologist and psychopharmacology and immunology specialist that has written this implausible article on microdosing psilocybin for the therapy of varied illnesses.

Right here you’ve gotten this attention-grabbing textual content!

Microdosing psilocybin is turning into more and more common

Information to microdosing psilocybin

Content material:

What’s in hallucinogenic mushrooms?

Mushrooms with hallucinogenic properties comprise two psychoactive alkaloids: psilocybin (4-phosphoryloxy-N, N-dimethyltryptamine) and psilocin (4-hydroxy-N, N-dimethyltryptamine). These chemical substances are discovered in numerous species of fungi, like these belonging to the genus Psilocybe, Panaeolus and Copelandia, and in addition in “magic truffles“, that are compact plenty of mycelium.

When ingesting these mushrooms, the psilocybin is metabolized and reworked into psilocin, the substance accountable for the psychoactive results induced by such a fungi. Mushrooms additionally comprise different compounds equivalent to baeocystin and norbaeocystin. These compounds are believed to modulate the mushrooms basic motion, as they don’t appear to have any psychoactive results of their very own. They almost certainly are accountable for the distinctive impact profile of every mushroom pressure, regardless that they comprise comparable doses of psilocybin and psilocin (1).

What’s Psilocybin and what are its results?

What’s microdosing?

The microdosing phenomenon, that’s, the common consumption of sub-perceptual quantities of psychedelics, like LSD or psilocybin mushrooms, has skilled an enormous reputation explosion in recent times, for the reason that publication of James Fadinam’s “The Psychedelic Explorer’s Information” in 2011. Microdosing will not be taking a low dose of a psychedelic and expertise the psychoactive results of the substance in a light method. Quite the opposite, microdosing consists within the ingestion of sub-psychoactive or sub-perceptual portions of a psychedelic, the place its results shall be very refined or fall beneath the perceptual degree, in order that you gained´t expertise any of the everyday visible or perceptual adjustments induced by a psychedelic substance.

A microdose is between 1/10 and 1/20 of a hallucinogenic dose. Microdosing is often built-in in your each day routine a number of occasions every week, in an effort to acquire the potential bodily and psychological advantages of the substance with out experiencing a state of altered consciousness. From the standpoint of a microdoser, it might be one thing like this: “I really feel productive, in a position to concentrate on what I select to do, I take pleasure in my relationships, I’ve vitality, and I don’t bear in mind taking something” (2).

What are psilocybin microdoses used for?

Analysis on microdosing remains to be in its infancy. In truth, at the moment, there aren´t any critical randomized placebo-controlled trials. The knowledge we have now comes from surveys and evaluation of hundreds of microdosers all through the world. Some on-line boards on microdosing have greater than 40.000 subscribers. These customers’ reviews recommend that mushrooms microdoses can enhance creativity, scale back migraines and cluster complications, relieve delicate despair, anxiousness and ache, and enhance focus.

A latest investigation on the consequences of microdoses of “magic truffles” means that this apply might enhance cognitive flexibility and the power to resolve issues. In keeping with the authors of the research, the microdosing of psilocybin mushrooms may very well be investigated within the close to future to assist individuals who undergo from inflexible thought or behaviour patterns equivalent to these with despair or Obsessive-Compulsive Dysfunction (OCD).

Can depression be treated with microdoses of psilocybin?

Can despair be handled with microdoses of psilocybin?

A latest exploratory evaluation has linked mushrooms microdoses with enhancements in temper, and with a lower in adverse emotionality and dysfunctional attitudes (anxiousness, rumination, depressed moods). The evaluation additionally mentions an enchancment in focus and the power to pay attention, interpersonal relations and social anxiousness, and an enhance of self-awareness and the power to meditate.

Nevertheless, the customers’ experiences may very well be mistaken for the placebo impact, as the themes know they’ve acquired a substance and due to this fact have sure expectations, or no less than the hope that mentioned substance will work. As well as, not all customers of microdoses appear to acquire the identical advantages; some are reporting elevated irritability, anxiousness, and confusion, poor reminiscence, and fatigue.

There’s a latest research with animals which is the primary to show that microdosing produces useful results on the temper and anxiousness in rats with experimentally induced post-traumatic stress dysfunction. This research used microdoses of dimethyltryptamine (DMT), a compound from the tryptamines household with hallucinogenic properties discovered within the Amazonian brew Ayahuasca, whose molecules have a really comparable construction to these of psilocybin. The constraints lie in whether or not these findings might be extrapolated to people.

Present scientific investigation on psychedelic psychotherapy has proven the therapeutic potential of full doses of psilocybin to alleviate treatment-resistant despair, OCD, alcohol and tobacco dependancy, and anxiousness in terminally unwell sufferers. Future research ought to decide if microdosing psilocybin can provide the identical advantages as a complete journey, and which protocols and microdoses could be most applicable.

Find out how to put together and use microdoses of mushrooms

You will need to notice that contemporary and dried mushrooms comprise completely different quantities of energetic rules. Psilocin is a extremely unstable molecule that begins degrading when it comes into contact with gentle or the oxygen within the air. For that reason, contemporary mushrooms are stronger, as they comprise each psilocybin and psilocin, whereas dry mushrooms are much less potent as a result of their psilocin has been degraded.

Fresh Psilocybe mushrooms

Recent Psilocybe mushrooms

The energetic rules are additionally discovered in numerous quantities relying on the kind of pressure, the way in which it’s been grown and dried, and its measurement; and even the completely different components of the mushroom (stem, cap) can comprise numerous quantities of alkaloids. Due to this fact, it is strongly recommended to dry and grind the mushrooms. When grinding the mushrooms, the completely different alkaloid content material within the caps and the stems balances itself, in addition to the completely different sizes of the mushrooms.

One microdose of Psilocybe cubensis consists of 0.1-0.5 grams of dry mushrooms. If you’ll use microdoses of psilocybin truffles, you’ve gotten to remember that dry truffles typically comprise much less psilocybin than dried mushrooms. You should use between 0.5 and 1 gram of dry powdered truffles per microdose. It’s not advisable to swap the mushrooms varieties in the course of the microdose protocol, as this might complicate the calibration of the dose when ingesting various quantities of the psychoactive substance for every pressure. strategy is to decide on one pressure to begin with, and maintain the protocol with the identical pressure till its completion.

You can begin by weighing round 0.1g of powder on a precision scale and use it as an preliminary microdose. After which regulate the quantity in response to the consequences of this primary dose. Microdosing on daily basis will not be advisable. Traditional psychedelics equivalent to psilocybin produce tolerance, so it’s attainable to really feel fewer results after just a few days. For that reason, James Fadiman, creator of “The Psychedelic Explorer´s Information”, suggests ready a few days between every microdose.

This manner, you’d be taking a microdose on day 1, not have any on days 2 and three, and take one once more on day 4. This course of continues for a number of weeks, taking each day notes in a journal, together with the times between takes, and recording the consequences within the precise second, and short-term and long-term adjustments in temper, vitality, and behavior.

Ideally, you can begin on a break day, in an effort to observe the consequences and be capable of regulate the dose with out an excessive amount of social interplay. The microdosing protocol needs to be integrated into your each day routine, which implies that you´ll know you take larger doses for those who expertise psychoactive results. Additionally, the microdosing quantities might be greater or decrease relying on the neurophysiology of every particular person, and an essential a part of the method is to search out the proper dose for every case. This course of can contain a number of makes an attempt, so it´s higher to begin from the underside till you discover your splendid psilocybin microdose.

Once harvested and dried, mushrooms can be easily dosed

As soon as harvested and dried, mushrooms might be simply dosed

Is psilocybin microdosing protected?

In keeping with all kinds of toxicological research and scientific trials, psilocybin has very low toxicity. Traditional hallucinogens equivalent to psilocybin work together primarily with the serotonin receptor 5-HT2A, which is accountable for the psychedelic results. Provided that power psychedelic consumption reduces the variety of 5-HT2A receptors, which results in a speedy and transient tolerance, the danger of dependancy to hallucinogens, psilocybin included, may be very low. As well as, psilocybin doesn’t instantly have an effect on the mesolimbic dopaminergic pathway, and due to this fact doesn’t activate the reward system.

One more reason why you shouldn´t take microdoses each day is that there’s a hypothetical threat, of which we nonetheless haven´t collected sufficient information, that would have an effect on the coronary heart valve of an individual who makes use of psychedelics steadily. Traditional psychedelics additionally work together with different receptors equivalent to 5-HT2B, that are additionally discovered within the coronary heart. Though psilocybin has a really low binding potential with this receptor (Ki = 4.6 nM), we nonetheless don´t have sufficient information to rule out this hypothetical hostile impact, and as a precautionary measure, and though it´s not identified how this threat its mirrored on the subject of microdosing, it’s best to keep away from microdosing too typically or for quite a lot of months per 12 months.

Microdoses of psilocybin, or different mind-altering medicine, can have potential dangers for individuals with psychological sicknesses equivalent to bipolar dysfunction or schizophrenia.
To see the potential interactions between microdoses and medicines, you may seek the advice of James Fadiman´s web site.


Ana Elda Maqueda

Scientific psychologist and psychopharmacology and immunology specialist


  • José Carlos Bouso Saiz, a number of authors. Psilocibes. Editorial: Ultrarradio / ICEERS
  • James Fadiman & Sophia Korb (2019). Would possibly Microdosing Psychedelics Be Secure and Helpful? An Preliminary Exploration Journal of Psychoactive Medicine, DOI: 10.1080/02791072.2019.1593561


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